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Comparative Study
. 2000 Apr;44(4):1085-8.
doi: 10.1128/AAC.44.4.1085-1088.2000.

Antipneumococcal activities of GAR-936 (a new glycylcycline) compared to those of nine other agents against penicillin-susceptible and -resistant pneumococci

D B Hoellman  1 , G A Pankuch, M R Jacobs, P C Appelbaum
Affiliations
Comparative Study

Antipneumococcal activities of GAR-936 (a new glycylcycline) compared to those of nine other agents against penicillin-susceptible and -resistant pneumococci

D B Hoellman et al. Antimicrob Agents Chemother. 2000 Apr.

Abstract

GAR-936, a new glycylcycline, had lower MICs (< or =0.016 to 0.125 microg/ml) for 201 penicillin- and tetracycline-susceptible and -resistant pneumococcal strains than tetracycline (< or = 0.06 to 128 microg/ml), minocycline (< or =0.06 to 16.0 microg/ml), or doxycycline (< or =0.06 to 32.0 microg/ml). GAR-936 was also bactericidal against 11 of 12 strains tested at the MIC after 24 h, with significant kill rates at earlier time points.

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Figures

FIG. 1
FIG. 1
Graphical depiction of GAR-936 kill kinetics versus a tetracycline-resistant (MIC, 64.0 μg/ml) strain of S. pneumoniae.
See this image and copyright information in PMC

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