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Review
. 1998;3(Suppl 3):45-55.

Molecular tools for the treatment of hepatitis C

J M Pawlotsky  1 , D R Gretch
Affiliations
  • PMID: 10726055
Review

Molecular tools for the treatment of hepatitis C

J M Pawlotsky et al. Antivir Ther. 1998.

Abstract

The treatment of chronic hepatitis C is aimed at eliminating viral replication in order to prevent further evolution towards cirrhosis and hepatocellular carcinoma. Virological parameters include hepatitis C virus (HCV) genotype, qualitative viraemia, quantitative viral load and the characteristics of HCV quasi-species heterogeneity. These parameters can be used to predict and monitor the response to therapy, in order to help clinicians to tailor treatment of chronic hepatitis C and to better understand the molecular mechanisms underlying HCV resistance to antiviral drugs. Current knowledge on these various issues is reviewed in the present article.

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