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. 1979 Mar 1;149(3):786-90.
doi: 10.1084/jem.149.3.786.

H-2-linked control of cytotoxic T-cell responsiveness to alphavirus infection. Presence of H-2Dk during differentiation and stimulation converts stem cells of low responder genotype to T cells of responder phenotype

A Mullbacher, R V Blanden

H-2-linked control of cytotoxic T-cell responsiveness to alphavirus infection. Presence of H-2Dk during differentiation and stimulation converts stem cells of low responder genotype to T cells of responder phenotype

A Mullbacher et al. J Exp Med. .

Abstract

Secondary Tc cells generated against Sindbis virus (SIN) are restricted to Dk. All other H-2K or D regions tested show low specific responsiveness. F1 hybrids between low and high responders show dominance of responsiveness but lack complementation. When BALB/c (KdIdDd) low responder fetal liver stem cells were allowed to mature in irradiated high responder recipients C3H.OH (KdIdDk) a response to Dk plus SIN could be generated with Tc cells of BALB/c origin. This result, together with the failure of complementation in the F1 hybrids, implies that the lesion of low responsiveness is in the inability of viral antigen to stimulate a Tc-cell response in association with any self H-2K or H-2D molecule (of those tested) other than H-2Dk. Hypotheses compatible with these data are discussed.

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References

    1. J Exp Med. 1978 Aug 1;148(2):534-43 - PubMed
    1. J Exp Med. 1978 Sep 1;148(3):805-10 - PubMed
    1. Nature. 1975 Mar 20;254(5497):269-70 - PubMed
    1. Scand J Immunol. 1977;6(5):533-9 - PubMed
    1. J Exp Med. 1977 Oct 1;146(4):909-22 - PubMed