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Review
. 2000 Jan 14;45(2):279-93.
doi: 10.1016/s0008-6363(99)00263-1.

Cardiac fatty acid uptake and transport in health and disease

G J van der Vusse  1 , M van Bilsen, J F Glatz
Affiliations
Review

Cardiac fatty acid uptake and transport in health and disease

G J van der Vusse et al. Cardiovasc Res. .

Abstract

Fatty acids are important energy donors for the healthy heart. These substrates are supplied to the myocardium bound to albumin to overcome their low solubility in aqueous solutions such as blood plasma. Transport from the microvascular compartment to the mitochondria inside the cardiomyocytes is most likely a combination of passive and protein-mediated diffusion. Alterations in tissue content of fatty acid-transport proteins may contribute to myocardial diseases such as the diabetic heart, and cardiac hypertrophy and failure.

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