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. 2000 Feb;23(1):17-21.
doi: 10.1007/BF02976459.

Synthesis and anti-inflammatory and analgesic activities of pyridyloxy- and phenoxyalkanoic acid derivatives

K H Shi  1 , S S Lim, S H Jung, J Ji, E B Lee, D C Kim, K J Shin, D J Kim, S W Park
Affiliations

Synthesis and anti-inflammatory and analgesic activities of pyridyloxy- and phenoxyalkanoic acid derivatives

K H Shi et al. Arch Pharm Res. 2000 Feb.

Abstract

Synthesis of pyridyloxy-, pyridyloxyphenoxy- and phenoxylphenoxyalkanate derivatives and their anti-inflammatory and analgesic activities were investigated. Analysis of structure-activity relationships showed that in pyridyloxyalkanoic acid derivatives anti-edematous potency was associated with the presence of chlorophenoxypropionic acid moiety and 2-nitrated methyl propionates contributed to the analgesic activity.

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