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Case Reports
. 2000 Apr 1;118(1):76-9.
doi: 10.1016/s0165-4608(99)00179-x.

A novel t(11;12)(q23-24;q24) in a case of minimally-differentiated acute myeloid leukemia (AML-M0)

M C Cox  1 , A Scanzani, G Del Poeta, A Venditti, P Panetta, V Derme, R Sgro, M Masi, S Amadori
Affiliations
Case Reports

A novel t(11;12)(q23-24;q24) in a case of minimally-differentiated acute myeloid leukemia (AML-M0)

M C Cox et al. Cancer Genet Cytogenet. .

Abstract

Acute myeloid leukemia with minimal signs of myeloid differentiation (AML-M0) is a recent addition to the FAB group classification. Chromosome data is scarce, but existing reports describe a high incidence of complex karyotypes and myelodysplastic syndrome-like chromosome alterations, while single chromosome translocations have rarely been reported. We describe the case of a 60-year-old woman diagnosed with AML-M0 with a novel translocation t(11;12)(q23-24;q24) as the sole karyotypic marker. Fluorescence in situ hybridization analysis to assess MLL gene splitting did not show rearrangement of this oncogene.

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