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Review
. 2000 Apr;20(8):2629-34.
doi: 10.1128/MCB.20.8.2629-2634.2000.

P-TEFb, a cyclin-dependent kinase controlling elongation by RNA polymerase II

D H Price  1
Affiliations
Review

P-TEFb, a cyclin-dependent kinase controlling elongation by RNA polymerase II

D H Price. Mol Cell Biol. 2000 Apr.
No abstract available

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Figures

FIG. 1
FIG. 1
Comparison of the cyclin box in human cyclins T1, T2, and K. Boldface reverse type designates identity in all three cyclins; boldface type, identity between K and either T1 or T2; uppercase letters, identity between T1 and T2; dot, nonidentity; dash, gap.
FIG. 2
FIG. 2
Model for recruitment of P-TEFb during T-cell activation. Before T-cell activation, the HIV LTR produces mostly short transcripts because of low levels of P-TEFb, comprised of Cdk9 and cyclin T1. As T cells are activated, cyclin T1 levels and then Tat levels rise. P-TEFb–Tat complexes form, associate with TAR, cause hyperphosphorylation of the CTD, and activate the LTR to produce full-length mRNAs.
See this image and copyright information in PMC

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