Review
[Structural and functional characteristics of ATP-dependent Lon-proteinase from Escherichia coli]
[Article in
Russian]
Affiliations
- PMID: 10734549
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Review
[Structural and functional characteristics of ATP-dependent Lon-proteinase from Escherichia coli]
[Article in
Russian]
Bioorg Khim.
1999 Dec.
Abstract
Enzymic and structural peculiarities of the ATP-dependent Lon protease from Escherichia coli and its mutant and modified forms were studied. Amino acid residues important for the function of proteolytic and ATPase sites and for the transmission of the interdomain signals of the activity coupling were found. It was shown that the protein substrates are hydrolyzed only by the full-size enzyme, whereas the isolated proteolytic domain displays a peptide-hydrolyzing activity.
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