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. 2000 Feb 28;149(1-2):21-9.
doi: 10.1016/s0304-3835(99)00328-6.

Prenylated chalcones and flavanones as inducers of quinone reductase in mouse Hepa 1c1c7 cells

C L Miranda  1 , G L Aponso, J F Stevens, M L Deinzer, D R Buhler
Affiliations

Prenylated chalcones and flavanones as inducers of quinone reductase in mouse Hepa 1c1c7 cells

C L Miranda et al. Cancer Lett. .

Abstract

The objective of this study was to determine if prenylchalcones (open C-ring flavonoids) and prenylflavanones from hops and beer are inducers of quinone reductase (QR) in the mouse hepatoma Hepa 1c1c7 cell line. All the prenylchalcones and prenylflavanones tested were found to induce QR but not CYP1A1 in this cell line. In contrast, the synthetic chalcone, chalconaringenin, and the flavanone, naringenin, with no prenyl or geranyl groups, were ineffective in inducing QR. The hop chalcones, xanthohumol and dehydrocycloxanthohumol hydrate, also induced QR in the Ah-receptor-defective mutant cell line, Hepa 1c1c7 bp(r)c1. Thus, the prenylflavonoids represent a new class of monofunctional inducers of QR.

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