Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2000 Jun 5;50(3):388-96.
doi: 10.1002/(sici)1097-4636(20000605)50:3<388::aid-jbm13>3.0.co;2-f.

Characterization of a polymeric PLGA-injectable implant delivery system for the controlled release of proteins

R E Eliaz  1 , J Kost
Affiliations

Characterization of a polymeric PLGA-injectable implant delivery system for the controlled release of proteins

R E Eliaz et al. J Biomed Mater Res. .

Abstract

Physico-chemical properties of injectable polymeric implant systems, based on the principle that a water-insoluble polymer dissolved in a biocompatible solvent will precipitate upon contact with water, were studied and utilized to predict the release of proteins from these systems. Polylactide-co-glycolide copolymer (PLGA) and glycofurol were chosen since they both have pharmaceutical precedence. Changes in polymer composition, its weight percent in solution, molecular weight, and protein loading level were assessed to provide formulations with the desired release rates and duration of release.

PubMed Disclaimer

LinkOut - more resources