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Review
. 2000 Apr;89(4):443-56.
doi: 10.1002/(SICI)1520-6017(200004)89:4<443::AID-JPS2>3.0.CO;2-W.

Chemical stability of nucleic acid-derived drugs

D Pogocki  1 , C Schöneich
Affiliations
Review

Chemical stability of nucleic acid-derived drugs

D Pogocki et al. J Pharm Sci. 2000 Apr.

Abstract

Nucleic acid-derived drugs exhibit both chemical and physical instability. This mini-review focuses on the prevalent hydrolytic and oxidative pathways of chemical degradation as they are affected by various endogenous (primary structure, chemical modifications in bases, sugars and phosphate residues) and exogenous (pH, buffer concentration, metal cation presence, oxygen presence) factors.

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