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. 2000 Mar;73(3):158-63.
doi: 10.1002/(sici)1096-9098(200003)73:3<158::aid-jso9>3.0.co;2-n.

Aberrations of the K-ras, p53, and APC genes in extrahepatic bile duct cancer

T Suto  1 , W Habano, T Sugai, N Uesugi, O Funato, S Kanno, K Saito, S i Nakamura
Affiliations

Aberrations of the K-ras, p53, and APC genes in extrahepatic bile duct cancer

T Suto et al. J Surg Oncol. 2000 Mar.

Abstract

Background and objectives: The genetic alterations involved in extrahepatic bile duct (EHBD) cancer are poorly understood. Our aim was to identify aberrations of the K-ras, p53, and APC genes in EHBD cancer.

Methods: We investigated aberrations of these genes in 52 EHBD cancers using polymerase chain reaction (PCR) single-strand conformation polymorphism analysis, followed by direct sequence determination and a PCR restriction fragment length polymorphism assay.

Results: The K-ras, p53, and APC genes were mutated in 9.6%, 32.7%, and 0% of EHBD cancers, respectively. Loss of heterozygosity at the p53 and APC gene loci was identified in 15.6% and 38.5% of EHBD cancers, respectively.

Conclusions: Our results suggest that an unknown suppressor gene on 5q other than the APC gene may be responsible for EHBD cancer.

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