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. 2000 Mar 6;10(5):469-71.
doi: 10.1016/s0960-894x(00)00029-9.

Antimitotic activity of moroidin, a bicyclic peptide from the seeds of Celosia argentea

H Morita  1 , K Shimbo, H Shigemori, J Kobayashi
Affiliations

Antimitotic activity of moroidin, a bicyclic peptide from the seeds of Celosia argentea

H Morita et al. Bioorg Med Chem Lett. .

Abstract

A unique bicyclic peptide, moroidin (1), from the seeds of Celosia argentea (Amaranthaceae) strongly inhibited the polymerization of tubulin. The stereostructure of moroidin (1) was reinvestigated by spectroscopic data, chemical degradation, and molecular dynamics simulation.

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