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. 2000 Mar 6;10(5):513-5.
doi: 10.1016/s0960-894x(00)00027-5.

Antitumour benzothiazoles. Part 10: the synthesis and antitumour activity of benzothiazole substituted quinol derivatives

G Wells  1 , T D Bradshaw, P Diana, A Seaton, D F Shi, A D Westwell, M F Stevens
Affiliations

Antitumour benzothiazoles. Part 10: the synthesis and antitumour activity of benzothiazole substituted quinol derivatives

G Wells et al. Bioorg Med Chem Lett. .

Abstract

The synthesis of a series of new antitumour agents, the benzothiazole substituted quinol ethers and esters, is reported via the hypervalent iodine mediated oxidation of hydroxylated 2-phenylbenzothiazoles. The products were found to be active in vitro against human colon and breast cancer cell lines with IC50 values in the nanomolar range.

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