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Review
. 2000 Apr 3;149(1):13-6.
doi: 10.1083/jcb.149.1.13.

Pores in the wall: claudins constitute tight junction strands containing aqueous pores

S Tsukita  1 , M Furuse
Affiliations
Review

Pores in the wall: claudins constitute tight junction strands containing aqueous pores

S Tsukita et al. J Cell Biol. .
No abstract available

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Figures

Figure 1
Figure 1
Schematic drawing of TJs. At the most apical region of lateral membranes, TJs occur between two adjacent cells. TJs are composed of paired TJ strands, in which each TJ strand laterally and tightly associates with that in the apposing membrane of adjacent cells. Paired TJ strands are thought to contain aqueous pores. In transcellular and paracellular pathways, materials move across plasma membranes and TJs, respectively.
Figure 2
Figure 2
Membrane folding model of claudin-1. Both NH2 and COOH termini are located in the cytoplasm. Each circle corresponds to each amino acid residue.
Figure 3
Figure 3
Manner of interaction of heterogeneous claudin species within and between TJ strands. (a) L transfectants coexpressing two of claudin-1, -2, and -3 were cultured. (b) Two of the L transfectants singly expressing claudin-1, -2, or -3 were cocultured. (c) L transfectants expressing claudin-1 were cocultured with those coexpressing claudin-1 and -2.
Figure 4
Figure 4
Two types of paired strands: one composed of claudin-1 and -3 (left), and the other composed of claudin-1 and -2 (right). Asterisks, putative pores. See text for details.
See this image and copyright information in PMC

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