Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2000 Apr;38(4):1679-80.
doi: 10.1128/JCM.38.4.1679-1680.2000.

Pooling of urine specimens for detection of asymptomatic Chlamydia trachomatis infections by PCR in a low-prevalence population: cost-saving strategy for epidemiological studies and screening programs

S A Morré  1 , C J Meijer, C Munk, S Krüger-Kjaer, J F Winther, H O Jørgensens, A J van Den Brule
Affiliations

Pooling of urine specimens for detection of asymptomatic Chlamydia trachomatis infections by PCR in a low-prevalence population: cost-saving strategy for epidemiological studies and screening programs

S A Morré et al. J Clin Microbiol. 2000 Apr.

Abstract

Pooling, in groups of five, of urine specimens from asymptomatically infected men in a population with 4% prevalence, as determined by case finding, is 100% sensitive and specific and results in a 60.5% reduction in the number of tests needed. Pooling of urine specimens in groups of 10 for the estimation of population-based prevalence is 96.1% sensitive and 100% specific and saves 90% of the test costs.

PubMed Disclaimer

References

    1. Kacena K A, Quinn S B, Howell M R, Madico G E, Quinn T C, Gaydos C A. Pooling urine samples for ligase chain reaction screening for genital Chlamydia trachomatis infection in asymptomatic women. J Clin Microbiol. 1998;36:481–485. - PMC - PubMed
    1. Kline R L, Brothers T A, Brookmeyer R, Zeger S, Quinn T C. Evaluation of human immunodeficiency virus seroprevalence in population surveys using pooled sera. J Clin Microbiol. 1989;27:1449–1452. - PMC - PubMed
    1. Lan J, Van den Brule A J C, Hemrika D J, Risse E K J, Walboomers J M M, Schipper M E I, Meijer C J L M. Chlamydia trachomatis and ectopic pregnancy: retrospective analysis of salpingectomy specimens, endometrial biopsies and cervical smears. J Clin Pathol. 1995;48:815–819. - PMC - PubMed
    1. Morré S A, van Valkengoed I G M, de Jong A, Boeke A J P, van Eijk J T M, Meijer C J L M, van den Brule A J C. Mailed, home-obtained urine specimens: a reliable screening approach for asymptomatic Chlamydia trachomatis infections. J Clin Microbiol. 1999;37:976–980. - PMC - PubMed
    1. Morré S A, Van Valkengoed I G M, Moes R M, Boeke A J P, Meijer C J L M, Van den Brule A J C. Determination of the Chlamydia trachomatis prevalence in an asymptomatic screening population: performances of LCx and COBAS Amplicor tests in urine specimens. J Clin Microbiol. 1999;37:3092–3096. - PMC - PubMed

Publication types