Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2000 May 26;275(21):15685-90.
doi: 10.1074/jbc.M910152199.

A broad role for the zinc finger protein ZNF202 in human lipid metabolism

S Wagner  1 , M A Hess, P Ormonde-Hanson, J Malandro, H Hu, M Chen, R Kehrer, M Frodsham, C Schumacher, M Beluch, C Honer, M Skolnick, D Ballinger, B R Bowen
Affiliations
Free article

A broad role for the zinc finger protein ZNF202 in human lipid metabolism

S Wagner et al. J Biol Chem. .
Free article

Abstract

The ZNF202 gene resides in a chromosomal region linked genetically to low high density lipoprotein cholesterol in Utah families. Here we show that the ZNF202 gene product is a transcriptional repressor that binds to elements found predominantly in genes that participate in lipid metabolism. Among its targets are structural components of lipoprotein particles (apolipoproteins AIV, CIII, and E), enzymes involved in lipid processing (lipoprotein lipase, lecithin cholesteryl ester transferase), and several genes involved in processes related to energy metabolism and vascular disease. Based on the linkage and apparent transcriptional function of ZNF202, we propose that ZNF202 is a candidate susceptibility gene for human dyslipidemia.

PubMed Disclaimer

MeSH terms