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Review
. 2000 Apr;105(7):841-6.
doi: 10.1172/JCI9744.

Conditionally replicating herpes vectors for cancer therapy

R L Martuza  1
Affiliations
Review

Conditionally replicating herpes vectors for cancer therapy

R L Martuza. J Clin Invest. 2000 Apr.
No abstract available

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Figures

Figure 1
Figure 1
Targeting HSV to general cancer cell pathways: A general map of HSV-1 demonstrates the unique long (UL) and unique short (US) sequences of HSV-1 flanked by the long and short repeat sequences. Also shown are the mutations introduced to create the vector G207, which infects and lyses tumor cells efficiently but is not virulent in normal tissue, even the brain.
Figure 2
Figure 2
Targeting specific cancer cell types (reproduced from references and with permission). G92A expresses ICP4 under the control of an albumin promoter/enhancer sequence and preferentially replicates within albumin expressing cells. Albumin expressing human hepatomas grown in athymic mice are effectively treated by either one or two doses of G92A (left) whereas albumin non-expressing human prostate cancer cells are unaffected (right). In contrast, hrR3, an ICP6-deficient vector that is not promoter regulated is effective against either tumor type.
See this image and copyright information in PMC

References

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