doi: 10.1017/s0031182000050290.
Antigenic analysis of sequential erythrocytic stages of Plasmodium knowlesi
- PMID: 107503
- DOI: 10.1017/s0031182000050290
Item in Clipboard
Antigenic analysis of sequential erythrocytic stages of Plasmodium knowlesi
Parasitology.
1978 Dec.
Abstract
The antigenic composition of sequential erythrocytic stages of Plasmodium knowlesi has been compared by crossed immuno-electrophoresis using a pool of immune rhesus monkey antiserum. Eleven major parasite antigens have been identified; 9 are stage-independent, and 2 stage-dependent. Differences in the relative amount of the stage-independent antigens have been demonstrated and quantified. The distribution of antigens between parasites and schizont and infected red cell membranes has been examined. Only 6 of the 11 parasite antigens were exhibited by a schizont membrane preparation, all these antigens were also expressed by the intracellular parasite. Antigens exclusive to the schizont membrane were not demonstrated.
Similar articles
-
Fractionation of Plasmodium knowlesi-induced antigens of rhesus monkey erythrocyte membranes.Bull World Health Organ. 1979;57 Suppl 1(Suppl):115-21. Bull World Health Organ. 1979. PMID: 120762 Free PMC article.
-
Plasmodium knowlesi-induced antigens in membranes of parasitized rhesus monkey erythrocytes.Proc Natl Acad Sci U S A. 1978 Oct;75(10):4949-53. doi: 10.1073/pnas.75.10.4949. Proc Natl Acad Sci U S A. 1978. PMID: 105359 Free PMC article.
-
Two Plasmodium knowlesi-specific antigens on the surface of schizont-infected Rhesus monkey erythrocytes induce antibody production in immune hosts.J Exp Med. 1979 Jul 1;150(1):86-99. doi: 10.1084/jem.150.1.86. J Exp Med. 1979. PMID: 87490 Free PMC article.
-
Protective antigens of bloodstage Plasmodium knowlesi parasites.Philos Trans R Soc Lond B Biol Sci. 1984 Nov 13;307(1131):159-69. doi: 10.1098/rstb.1984.0116. Philos Trans R Soc Lond B Biol Sci. 1984. PMID: 6151680 Review.
-
Plasmodium knowlesi: a relevant, versatile experimental malaria model.Parasitology. 2018 Jan;145(1):56-70. doi: 10.1017/S0031182016002286. Epub 2016 Dec 12. Parasitology. 2018. PMID: 27938428 Review.
Cited by
-
Stage-specific proteins and glycoproteins of plasmodium falciparum: identification of antigens unique to schizonts and merozoites.Proc Natl Acad Sci U S A. 1980 Jun;77(6):3695-9. doi: 10.1073/pnas.77.6.3695. Proc Natl Acad Sci U S A. 1980. PMID: 6997881 Free PMC article.
-
Biosynthesis and processing of a Plasmodium falciparum schizont antigen recognized by immune serum and a monoclonal antibody.J Exp Med. 1982 Nov 1;156(5):1528-38. doi: 10.1084/jem.156.5.1528. J Exp Med. 1982. PMID: 6752328 Free PMC article.
-
Delineation of stage specific expression of Plasmodium falciparum EBA-175 by biologically functional region II monoclonal antibodies.PLoS One. 2011 Apr 14;6(4):e18393. doi: 10.1371/journal.pone.0018393. PLoS One. 2011. PMID: 21533224 Free PMC article.
-
Monoclonal antibodies to stage-specific, species-specific, and cross-reactive antigens of the rodent malarial parasite, Plasmodium yoelii.Infect Immun. 1981 May;32(2):563-70. doi: 10.1128/iai.32.2.563-570.1981. Infect Immun. 1981. PMID: 6166558 Free PMC article.
-
Rhesus monkeys protected against Plasmodium knowlesi malaria produce antibodies against a 65,000-MrP. knowlesi glycoprotein at the surface of infected erythrocytes.Infect Immun. 1981 Nov;34(2):519-25. doi: 10.1128/iai.34.2.519-525.1981. Infect Immun. 1981. PMID: 7309238 Free PMC article.