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Review
. 2000 Apr;10(2):266-73.
doi: 10.1016/s0959-4388(00)00070-2.

Linking Hebb's coincidence-detection to memory formation

J Z Tsien  1
Affiliations
Review

Linking Hebb's coincidence-detection to memory formation

J Z Tsien. Curr Opin Neurobiol. 2000 Apr.

Abstract

The theoretical foundations of learning and memory were laid by Donald Hebb 50 years ago. Recent genetic experiments that enhanced coincidence-detection of the NMDA receptor (a molecular master-switch in implementing Hebb's rule) and that led to better learning and memory in adult animals have substantially validated Hebb's rule in memory formation in the brain.

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