Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2000 May-Jun;21(3):135-8.
doi: 10.1159/000030119.

Homozygous arginine at codon 72 of p53 has no prognostic significance in cervical cancer

H Y Ngan  1 , V W Liu, S S Liu, D K Cheng, T Y Ng, L C Wong
Affiliations
Free article

Homozygous arginine at codon 72 of p53 has no prognostic significance in cervical cancer

H Y Ngan et al. Tumour Biol. 2000 May-Jun.
Free article

Abstract

Mutation of p53, a tumour suppressor gene, is uncommon in cervical cancer but the detection of human papillomavirus (HPV) DNA in cervical cancer is common. The findings of increased susceptibility to degradation of p53 by E6 protein of HPV16/18 in cervical cancer with homozygous arginine at codon 72 (HA72) of p53 led to this study on whether cervical cancers with HA72 were more aggressive with the increase in the rate of loss of p53 function. In 102 cervical cancers, 76.5% were HPV16/18 positive and 30% had HA72. No survival difference was detected between HA72 and non-HA72 tumours irrespective of HPV16/18 status. Furthermore, the detection of HPV16/18 in cervical cancer was found not to be of prognostic significance in this study.

PubMed Disclaimer

MeSH terms