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Review
. 2000 Apr;25(4):173-8.
doi: 10.1016/s0968-0004(00)01560-7.

Replication fork arrest and DNA recombination

Affiliations
Review

Replication fork arrest and DNA recombination

B Michel. Trends Biochem Sci. 2000 Apr.

Abstract

Replication arrests are associated with genome rearrangements, which result from either homologous or non-homologous recombination. Interestingly, proteins involved in homologous recombination are able to convert an arrested replication fork into a recombination intermediate, which promotes replication restart and thus presumably prevents genome rearrangements.

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