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Clinical Trial
. 2000 Jan;17(1):28-33.
doi: 10.1023/a:1009445913156.

The effects of E2 supplementation from the early proliferative phase to the late secretory phase of the endometrium in hMG-stimulated IVF-ET

H Jung  1 , H K Roh
Affiliations
Clinical Trial

The effects of E2 supplementation from the early proliferative phase to the late secretory phase of the endometrium in hMG-stimulated IVF-ET

H Jung et al. J Assist Reprod Genet. 2000 Jan.

Abstract

Purpose: Our purpose was to determine if pregnancy rates (PRs) for hMG (human menopausal gonadotropin)-stimulated IVF-ET (in vitro fertilization--embryo transfer) can be increased by estradiol (E2) supplementation from the early proliferative phase to the late secretory phase of the endometrium.

Method: Eighty-one infertile women with pure tubal factor were randomized into two groups. One group received no E2 supplementation (control group) and the other received oral E2 supplementation (2 mg two times daily) from the early proliferative phase starting on the third day of the menstrual cycle to the late secretory phase of the endometrium, with hMG stimulation for ovulation induction starting on the sixth day of the menstrual cycle.

Results: In 85 cycles, at least one embryo was transferred. Compared with the control group (n = 27 cycles), the E2 supplementation group (n = 58 cycles) had a significantly higher PR (control, 25.9%, versus E2 supplementation, 48.3%) and IR per ET (control, 10%, versus E2 supplementation, 26%), but FRs per retrieved oocytes were not statistically different between the two groups (control, 74%, versus E2 supplementation group, 73%). Four spontaneous abortions occurred in the E2 supplementation group, and one case in the control group. Ectopic pregnancy occurred in one case in the control group.

Conclusions: Clinical PRs and IRs in the E2 supplementation group were significantly higher than in the control group, while FRs in the control group did not differ statistically from the E2 supplementation group. This suggests that E2 supplementation from the early proliferative phase to the late secretory phase of the endometrium in hMG-stimulated IVF-ET increases the receptivity of the endometrium for transferred embryos and clinical PRs.

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References

    1. Edwards RG. Clinical approaches to increasing uterine receptivity during human implantation. Hum Reprod. 1995;10(Suppl2):60–66. - PubMed
    1. Lewin A, Benshushan A, Mezker E, Yanai N, Schenker JG, Goshen R. The role of estrogen support during luteal phase of in vitro fertilization-embryo transplant cycles: A comparative study between progesterone alone and estrogen and progesterone support. Fertil Steril. 1994;62(1):121–125. - PubMed
    1. Buttram VC, Turati G. Uterine synechiae: Variations in severity and some conditions which may be conducive to severe adhesions. Int J Fertil. 1977;22:98–103. - PubMed
    1. Katzenellenbogen BS. Dynamics of steroid hormone receptor action. Annu Rev Physiol. 1980;42:17–35. - PubMed
    1. Gonen Y, Casper RF, Jacobson W, Blankier J. Endometrial thickness and growth during ovarian stimulation: A possible predictor of implantation in in vitro fertilization. Fertil Steril. 1989;52(3):446–450. - PubMed

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