[The clinical, imaging and electrophysiological correlations in Paget's disease]

Abstract

The work presents two cases of Paget disease with a complex neurological description. The first case, a woman of 59 years, presents a spastic paraparesis with multiple syndrome of cranial nerves. The second case, a woman of 60 years, presents a spastic tetraparesis with myoclonus. The cranial radiography stood out to both patients the thickness of the bones of the skull in the context of the existence of some grown titres of the alkaline phosphate. The examination CT to the second patient indicates an important cerebral atrophy. Auditory evoked potentials (AEPs) show to the first patient the increasing in time of the latency of the first wave and to the second patient the inequality of latency from the right to left a wave I and the growing latency of the interval I-III to the left. Visual evoked potentials (VEPs) to the second patient indicate the delay of all the component parts. If the radiological examination asserts the diagnosis, the electrophysiological probings diagnose the complications and the evolution of the disease.