Review
doi: 10.1016/s1286-4579(00)00299-9.
CR3: a general purpose adhesion-recognition receptor essential for innate immunity
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- PMID: 10758405
- DOI: 10.1016/s1286-4579(00)00299-9
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Review
CR3: a general purpose adhesion-recognition receptor essential for innate immunity
Microbes Infect.
2000 Mar.
Free article
Abstract
CR3 (CD11b/CD18), a beta(2) integrin, has a key role in innate antimicrobial defenses, as evidenced by the leukocyte adhesion (CD18) deficiency syndrome in humans and the CD11b knockout mouse. CR3 is a highly versatile pattern-recognition receptor that activates leukocytes via signaling complexes and actin reorganization, mediates phagocytosis, and promotes leukocyte transmigration.
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