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Review
. 2000 Mar;2(3):289-94.
doi: 10.1016/s1286-4579(00)00299-9.

CR3: a general purpose adhesion-recognition receptor essential for innate immunity

M R Ehlers  1
Affiliations
Free article
Review

CR3: a general purpose adhesion-recognition receptor essential for innate immunity

M R Ehlers. Microbes Infect. 2000 Mar.
Free article

Abstract

CR3 (CD11b/CD18), a beta(2) integrin, has a key role in innate antimicrobial defenses, as evidenced by the leukocyte adhesion (CD18) deficiency syndrome in humans and the CD11b knockout mouse. CR3 is a highly versatile pattern-recognition receptor that activates leukocytes via signaling complexes and actin reorganization, mediates phagocytosis, and promotes leukocyte transmigration.

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