Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2000 Apr 11;97(8):3792-4.
doi: 10.1073/pnas.97.8.3792.

Filling in the GAPs in the ADP-ribosylation factor story

Affiliations
Comment

Filling in the GAPs in the ADP-ribosylation factor story

J G Donaldson. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Schematic representation of the ARF GAP proteins. All have the ARF GAP domain (GAP, black) that includes the Zn-finger motif. ASAP1 and PAP also have a pleckstrin homology (PH) domain (PH, horizontal stripes), ankyrin repeats (Ank. Rep., diagonal stripes), a stretch of proline-rich sequences (PR), and an SH3 domain (SH3, gray). There are two forms of PAP, α and β, but one is shown for simplicity. The Git, Cat, and Pkl GAPs have proline-rich sequences, but no PH or SH3 domains. Asterisks denote that GAP activity for these proteins has not been demonstrated. Peripheral GAPs refers to ASAP1, PAP, Git1, Cat2, Pkl, and centaurin-α.

Comment on

References

    1. Moss J, Vaughan M. J Biol Chem. 1998;273:21431–21434. - PubMed
    1. Chavrier P, Goud B. Curr Opin Cell Biol. 1999;11:466–475. - PubMed
    1. Randazzo P A, Andrade J, Miura K, Brown M T, Long Y-Q, Stauffer S, Roller P, Cooper J A. Proc Natl Acad Sci USA. 2000;97:4011–4016. - PMC - PubMed
    1. Brown M T, Andrade J, Radhakrishna H, Donaldson J G, Cooper J A, Randazzo P A. Mol Cell Biol. 1998;18:7038–7051. - PMC - PubMed
    1. Burridge K, Chrzanowska-Wodnicka M. Annu Rev Cell Dev Biol. 1996;12:463–519. - PubMed

MeSH terms

LinkOut - more resources