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Clinical Trial
. 2000 Apr 25;54(8):1698-700.
doi: 10.1212/wnl.54.8.1698.

Abnormalities in CSF concentrations of ferritin and transferrin in restless legs syndrome

C J Earley  1 , J R Connor, J L Beard, E A Malecki, D K Epstein, R P Allen
Affiliations
Clinical Trial

Abnormalities in CSF concentrations of ferritin and transferrin in restless legs syndrome

C J Earley et al. Neurology. .

Abstract

CSF and serum were obtained from 16 patients with idiopathic restless legs syndrome (RLS) and 8 age-matched healthy control subjects. Patients with RLS had lower CSF ferritin levels (1. 11 +/- 0.25 ng/mL versus 3.50 +/- 0.55 ng/mL; p = 0.0002) and higher CSF transferrin levels (26.4 +/- 5.1 mg/L versus 6.71 +/- 1.6 mg/L; p = 0.018) compared with control subjects. There was no difference in serum ferritin and transferrin levels between groups. The presence of reduced ferritin and elevated transferrin levels in CSF is indicative of low brain iron in patients with idiopathic RLS.

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