[The effect of GABA-positive agents on the formation of morphine dependence and on the manifestations of a withdrawal syndrome]
[Article in
Russian]
Affiliations
- PMID: 10763104
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[The effect of GABA-positive agents on the formation of morphine dependence and on the manifestations of a withdrawal syndrome]
[Article in
Russian]
Eksp Klin Farmakol.
2000 Jan-Feb.
Abstract
Experiments on mice showed that the GABA-positive preparations (THIP, baclofen, fenibut, valproate sodium) intraperitoneally injected in the course of the morphine addiction development (double daily subcutaneous injections at a dose increasing from 10 to 100 mg/kg over a period of 8 days) and, to a greater extent, upon cessation of the morphine injections, partly reduce manifestations of the naloxone-enhanced (0.1 mg/kg, s.c.) daily abstinence, as evaluated by the hopping activity and pair interaction tests.
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