Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1999;4(4):329-36.

Estimating sensitivity and specificity when repeated tests are performed on the same subject

G Ronco  1 , A Biggeri
Affiliations
  • PMID: 10764247

Estimating sensitivity and specificity when repeated tests are performed on the same subject

G Ronco et al. J Epidemiol Biostat. 1999.

Abstract

Background: When diagnostic tests are repeated on the same subject, a correlation between test results is expected. This must be taken into account when computing interval estimates.

Methods: The application of regression techniques for correlated data to a logistic model is proposed in order to obtain correct point and interval estimates.

Results: The use of different study designs and models of analysis (marginal and 'random effects') is discussed. The advantages of studies using multiple tests, possible sources of bias (including those specific to multiple testing) and methods of correction are also discussed. An example considering Doppler flow velocimetry in pregnancy is presented.

PubMed Disclaimer

Publication types