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Comment
. 2000 Apr 6;404(6778):560-1.
doi: 10.1038/35007187.

Cell cycle. A new check on issuing the licence

J J Blow, S Tada
Comment

Cell cycle. A new check on issuing the licence

J J Blow et al. Nature. .
No abstract available

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Figures

Figure 1
Figure 1
Steps in the licensing of a DNA replication origin. a, Cdt1 (as shown by Nishitani et al. and Maiorano et al.) and Cdc6/Cdc18 bind to the origin-recognition complex (ORC) at an origin of DNA replication. b, Several MCM protein complexes, represented by ‘M’, are then assembled onto the origin to ‘license’ it for replication. The activity of replication-licensing factor B (RLF-B) might be involved at this point. c, As a consequence of replication licensing, Cdc6/Cdc18 is displaced from the origin. d, As DNA replication starts, all of the Cdt1 is removed from the origins. MCM proteins are removed as the DNA replicates.
See this image and copyright information in PMC

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References

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