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Clinical Trial
. 2000 May-Jun;7(3):485-90.
doi: 10.3892/or.7.3.485.

A phase III randomized study comparing doxifluridine and 5-fluorouracil as supportive chemotherapy in advanced and recurrent gastric cancer

K Kondo  1 , J Sakamoto, H Nakazato, A Koike, T Kitoh, K Hachisuka, S Saji, J Yura, Y Nimura, N Hamajima, K Katoh, A Yamaguchi, K I Miya, M Yamauchi, I Mizuno, M Nagino, H Takagi
Affiliations
Clinical Trial

A phase III randomized study comparing doxifluridine and 5-fluorouracil as supportive chemotherapy in advanced and recurrent gastric cancer

K Kondo et al. Oncol Rep. 2000 May-Jun.

Abstract

We conducted a phase III randomized study to investigate effects of supportive chemotherapy with oral doxifluridine (group A, 75 patients) or 5-fluorouracil (group B, 75 patients) in advanced gastric cancer when intensive chemotherapy was not an option. Although there were no significant differences between the groups with regard to survival, hospital-free survival and time to progression, median values of 3 endpoints were superior in group A. Secondary analysis showed that group A patients with prior chemotherapy tended to have longer survival and hospital-free survival and significantly longer time to progression.

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