Review
doi: 10.1016/s0531-5565(99)00095-9.
Age-dependent changes in B lymphocyte development in man and mouse
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- PMID: 10767576
- DOI: 10.1016/s0531-5565(99)00095-9
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Review
Age-dependent changes in B lymphocyte development in man and mouse
Exp Gerontol.
2000 Mar.
Abstract
In recent years, detailed analyses of B cell development in both humans and mice have revealed similar subsets of precursors along the same pathway of differentiation. From these studies it also became clear that both species undergo age related changes in this B lymphocyte development program. In this review we summarize these findings and discuss, potential mechanisms underlying these age related changes, and possible causative correlations between these changes and age related B cell abnormalities.
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