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. 2000 Mar 18;355(9208):1008-10.
doi: 10.1016/S0140-6736(00)90002-3.

Thiazolidinediones: an update

K Schoonjans  1 , J Auwerx
Affiliations

Thiazolidinediones: an update

K Schoonjans et al. Lancet. .

Abstract

Thiazolidinediones, which are being developed for the treatment of insulin resistance and type 2 diabetes mellitus, bind and activate peroxisome proliferator-activated receptor gamma, a nuclear receptor that regulates the expression of several genes involved in metabolism. This receptor controls adipocyte differentation, lipid storage, and insulin sensitisation. Besides metabolic activities, thiazolidinediones have effects as diverse as the control of host defence, cell proliferation, and tumorigenesis.

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  • Information on thiazolidinediones.
    Wolfe SM, Lurie P, Sasich LD, Barbehenn E. Wolfe SM, et al. Lancet. 2000 Jul 15;356(9225):254-5. doi: 10.1016/S0140-6736(05)74507-4. Lancet. 2000. PMID: 10963229 No abstract available.

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