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. 2000 May;44(5):1159-62.
doi: 10.1128/AAC.44.5.1159-1162.2000.

SCH 56592, amphotericin B, or itraconazole therapy of experimental murine cerebral phaeohyphomycosis due to Ramichloridium obovoideum ("Ramichloridium mackenziei")

H M Al-Abdely  1 , L Najvar, R Bocanegra, A Fothergill, D Loebenberg, M G Rinaldi, J R Graybill
Affiliations

SCH 56592, amphotericin B, or itraconazole therapy of experimental murine cerebral phaeohyphomycosis due to Ramichloridium obovoideum ("Ramichloridium mackenziei")

H M Al-Abdely et al. Antimicrob Agents Chemother. 2000 May.

Abstract

Ramichloridium obovoideum ("Ramichloridium makenziei") is a rare cause of lethal cerebral phaeohyphomycosis. It has been, so far, geographically restricted to the Middle East. BALB/c mice were inoculated with two strains of R. obovoideum intracranially. Therapy with amphotericin B, itraconazole, or the investigational triazole SCH 56592 was conducted for 10 days. Half the mice were monitored for survival and half were killed for determination of the fungal load in brain tissue. Recipients of SCH 56592 had significantly prolonged survival and lower brain fungal burden, and this result was found for mice infected with both of the fungal strains tested. Itraconazole reduced the brain fungal load in mice infected with one strain but not the other, while amphotericin B had no effect on brain fungal concentrations. This study indicates a possible role of SCH 56592 in the treatment of the serious cerebral phaeohyphomycosis due to R. obovoideum.

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Figures

FIG. 1
FIG. 1
Survival times for immunosuppressed and immunocompetent ICR mice infected with R. obovoideum 653 intravenously (IV) or intracranially (IC) (A) and brain fungal concentrations at day 11 postinfection (B).
FIG. 2
FIG. 2
Survival times (A) and brain fungal burdens (B) for BALB/c mice infected with R. obovoideum 653 intracranially and treated with amphotericin B (AMB) at 3 mg/kg/day, itraconazole (ITR) at 30 mg/kg three times daily, and SCH 56592 at 50 mg/kg/day for 10 days.
FIG. 3
FIG. 3
Survival times (A) and brain fungal burdens (B) for BALB/c mice infected with R. obovoideum 95-1147 intracranially and treated with amphotericin B (AMB) at 3 mg/kg/day, itraconazole (ITR) at 30 mg/kg three times daily, and SCH 56592 at 50 mg/kg/day for 10 days.
See this image and copyright information in PMC

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