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. 2000 Apr;105(8):1035-8.
doi: 10.1172/JCI9871.

Reovirus as a novel oncolytic agent

K L Norman  1 , P W Lee
Affiliations

Reovirus as a novel oncolytic agent

K L Norman et al. J Clin Invest. 2000 Apr.
No abstract available

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Figures

Figure 1
Figure 1
Usurpation of the Ras signaling pathway by reovirus. In untransformed, reovirus-resistant cells, double-stranded RNA structures in reovirus transcripts activate PKR, which subsequently phosphorylates eIF-2α, inhibiting translation initiation of viral genes. In cells with an activated Ras signaling pathway, however, PKR phosphorylation in response to viral transcripts is inhibited and viral translation proceeds unimpeded.
See this image and copyright information in PMC

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