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. 1999 Oct;43(4):505-9.

Effect of Panax ginseng and diazepam on brain 5-hydroxytryptamine and its modification by diclofenac in rat

D Bhattcharyya  1 , T K Sur
Affiliations
  • PMID: 10776470

Effect of Panax ginseng and diazepam on brain 5-hydroxytryptamine and its modification by diclofenac in rat

D Bhattcharyya et al. Indian J Physiol Pharmacol. 1999 Oct.

Abstract

Wistar male rats pretreated with anti-stress agents like, Panax ginseng (Pg) and diazepam (Diaz) were stressed by restraining for 1 h and 5-HT content of brain and hypothalamus as well as plasma corticosterone were measured spectrophotoflurometrically. Diclofenac (DICLO), a prostaglandin (PG) synthesis inhibitor was used to confirm the role of prostaglandin in restraint stress-induced elevation of central 5-HT correspondingly confirmed by elevation of plasma corticosterone and modification of the above anti-stress agents. Pg, Diaz and DICLO per se did not modify brain and hypothalamic 5-HT in control rats. But they attenuated stress-induced elevation of brain and hypothalamic 5-HT. Anti-stress action of both Pg and Diaz reflected by inhibition of stress-induced elevation of brain and hypothalamic content of 5-HT as also stress-induced concurrent elevation of plasma corticosterone were further diminished by DICLO. The mediatory action of 5-HT in anti-stress effects of Pg and Diaz may be modulated through prostaglandins.

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