Lateral diffusion of membrane proteins in the presence of static and dynamic corrals: suggestions for appropriate observables
- PMID: 10777724
- PMCID: PMC1300817
- DOI: 10.1016/S0006-3495(00)76772-5
Lateral diffusion of membrane proteins in the presence of static and dynamic corrals: suggestions for appropriate observables
Abstract
We consider the possibility of inferring the nature of cytoskeletal interaction with transmembrane proteins via optical experiments such as single-particle tracking (SPT) and near-field scanning optical microscopy (NSOM). In particular, we demonstrate that it may be possible to differentiate between static and dynamic barriers to diffusion by examining the time-dependent variance and higher moments of protein population inside cytoskeletal "corrals." Simulations modeling Band 3 diffusion on the surface of erythrocytes provide a concrete demonstration that these statistical tools might prove useful in the study of biological systems.
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