Structure and mechanisms of function of visual system proteins
- PMID: 10779170
Structure and mechanisms of function of visual system proteins
Abstract
Recent progress in understanding visual signal transduction in retinal cells is summarized. The roles of particular proteins in activation, amplification and termination of the photoresponse are described. Detailed information on the structure and function of the photoreceptor protein rhodopsin is presented. The latest data on visual pigment sequences, rhodopsin mutations in the autosomal-dominant retinitis pigmentosa, and the results of site-directed mutagenesis of the rhodopsin molecule are summarized.
Similar articles
-
Mechanisms of cell death in rhodopsin retinitis pigmentosa: implications for therapy.Trends Mol Med. 2005 Apr;11(4):177-85. doi: 10.1016/j.molmed.2005.02.007. Trends Mol Med. 2005. PMID: 15823756 Review.
-
Rhodopsin and phototransduction.J Photochem Photobiol B. 1999 Jan;48(1):1-10. doi: 10.1016/S1011-1344(99)00200-6. J Photochem Photobiol B. 1999. PMID: 10205874 Review.
-
Comparison of the retinitis pigmentosa mutations in rhodopsin with a functional map of the C5a receptor.Vision Res. 2006 Dec;46(27):4519-31. doi: 10.1016/j.visres.2006.07.010. Epub 2006 Sep 8. Vision Res. 2006. PMID: 16962629
-
A role for rhodopsin in a signal transduction cascade that regulates membrane trafficking and photoreceptor polarity.Vision Res. 2006 Dec;46(27):4427-33. doi: 10.1016/j.visres.2006.07.028. Epub 2006 Sep 28. Vision Res. 2006. PMID: 17010408 Review.
-
Retinopathy mutations in the bZIP protein NRL alter phosphorylation and transcriptional activity.Hum Mutat. 2007 Jun;28(6):589-98. doi: 10.1002/humu.20488. Hum Mutat. 2007. PMID: 17335001
Cited by
-
Salmonid opsin sequences undergo positive selection and indicate an alternate evolutionary relationship in oncorhynchus.J Mol Evol. 2004 Apr;58(4):400-12. doi: 10.1007/s00239-003-2562-y. J Mol Evol. 2004. PMID: 15114419