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Review
. 2000 Jun;12(3):282-8.
doi: 10.1016/s0952-7915(00)00088-1.

Tec family kinases in lymphocyte signaling and function

E M Schaeffer  1 , P L Schwartzberg
Affiliations
Review

Tec family kinases in lymphocyte signaling and function

E M Schaeffer et al. Curr Opin Immunol. 2000 Jun.

Abstract

The Tec kinases are required for full Ca(2+) mobilization in lymphocytes. Recent data suggest that this process occurs via a multiprotein complex that includes LAT and SLP-76 in T cells and BLNK/SLP-65 in B cells. Mutational analyses have revealed critical roles for Tec kinases in lymphocyte development and function.

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