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. 2000 Apr 17;10(8):801-4.
doi: 10.1016/s0960-894x(00)00100-1.

Incorporation of a 4-hydroxy-N-acetylprolinol nucleotide analogue improves the 3'-exonuclease stability of 2'-5'-oligoadenylate-antisense conjugates

J C Verheijen  1 , A M van Roon, N J Meeuwenoord, H R Stuivenberg, S F Bayly, L Chen, G A van der Marel, P F Torrence, J H van Boom
Affiliations

Incorporation of a 4-hydroxy-N-acetylprolinol nucleotide analogue improves the 3'-exonuclease stability of 2'-5'-oligoadenylate-antisense conjugates

J C Verheijen et al. Bioorg Med Chem Lett. .

Abstract

Incorporation of a 4-hydroxy-N-acetylprolinol nucleotide analogue at the 3'-terminus of DNA or 2-5A-DNA sequences resulted in a significantly enhanced 3'-exonuclease resistance while the affinity for complementary RNA was only slightly decreased. Furthermore, the binding to and activation of human RNase L by thus modified 2-5A-DNA conjugates was not altered as compared to the parent unmodified 2-5A-DNAs.

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