Review
doi: 10.1038/35008681.
mRNA export: the long and winding road
- PMID: 10783248
- DOI: 10.1038/35008681
Item in Clipboard
Review
mRNA export: the long and winding road
Nat Cell Biol.
2000 Apr.
Abstract
To the growing list of factors required for the export of messenger RNA from nucleus to cytoplasm can now be added Yra1. Yeast Yra1 and its metazoan orthologues bind mRNAs and interact with multiple mRNA export factors. Transport of proteins and small RNAs does not require Yra1 or any other proteins required for mRNA export, suggesting that mRNA export may proceed by a different mechanism. The finding that Yra1 has a role in mRNA export moves us one step closer to identifying all the proteins required for this process.
Similar articles
-
Messenger RNAs are recruited for nuclear export during transcription.Genes Dev. 2001 Jul 15;15(14):1771-82. doi: 10.1101/gad.892401. Genes Dev. 2001. PMID: 11459827 Free PMC article.
-
Genome-wide analysis of RNA-protein interactions illustrates specificity of the mRNA export machinery.Nat Genet. 2003 Feb;33(2):155-61. doi: 10.1038/ng1080. Epub 2003 Jan 13. Nat Genet. 2003. PMID: 12524544
-
Splicing factor Sub2p is required for nuclear mRNA export through its interaction with Yra1p.Nature. 2001 Oct 11;413(6856):648-52. doi: 10.1038/35098113. Nature. 2001. PMID: 11675790
-
Formation of export-competent mRNP: escaping nuclear destruction.Curr Opin Cell Biol. 2005 Jun;17(3):287-93. doi: 10.1016/j.ceb.2005.04.009. Curr Opin Cell Biol. 2005. PMID: 15901499 Review.
-
Nuclear export of mRNA: from the site of transcription to the cytoplasm.Exp Cell Res. 2004 May 15;296(1):12-20. doi: 10.1016/j.yexcr.2004.03.015. Exp Cell Res. 2004. PMID: 15120988 Review.
Cited by
-
Biogenesis of the signal recognition particle (SRP) involves import of SRP proteins into the nucleolus, assembly with the SRP-RNA, and Xpo1p-mediated export.J Cell Biol. 2001 May 14;153(4):745-62. doi: 10.1083/jcb.153.4.745. J Cell Biol. 2001. PMID: 11352936 Free PMC article.
-
Rpb4p, a subunit of RNA polymerase II, mediates mRNA export during stress.Mol Biol Cell. 2003 Jul;14(7):2744-55. doi: 10.1091/mbc.e02-11-0740. Mol Biol Cell. 2003. PMID: 12857861 Free PMC article.
-
The nuclear export receptor Xpo1p forms distinct complexes with NES transport substrates and the yeast Ran binding protein 1 (Yrb1p).Mol Biol Cell. 2001 Mar;12(3):539-49. doi: 10.1091/mbc.12.3.539. Mol Biol Cell. 2001. PMID: 11251069 Free PMC article.
-
Nuclear mRNA export requires specific FG nucleoporins for translocation through the nuclear pore complex.J Cell Biol. 2007 Sep 24;178(7):1121-32. doi: 10.1083/jcb.200704174. Epub 2007 Sep 17. J Cell Biol. 2007. PMID: 17875746 Free PMC article.
-
The mRNA export factor Dbp5 is associated with Balbiani ring mRNP from gene to cytoplasm.EMBO J. 2002 Mar 1;21(5):1177-87. doi: 10.1093/emboj/21.5.1177. EMBO J. 2002. PMID: 11867546 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
