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. 2000 Apr 28;288(5466):675-8.
doi: 10.1126/science.288.5466.675.

Control of homeostasis of CD8+ memory T cells by opposing cytokines

C C Ku  1 , M Murakami, A Sakamoto, J Kappler, P Marrack
Affiliations

Control of homeostasis of CD8+ memory T cells by opposing cytokines

C C Ku et al. Science. .

Abstract

Memory T cells maintain their numbers for long periods after antigen exposure. Here we show that CD8+ T cells of memory phenotype divide slowly in animals. This division requires interleukin-15 and is markedly increased by inhibition of interleukin-2 (IL-2). Therefore, the numbers of CD8+ memory T cells in animals are controlled by a balance between IL-15 and IL-2.

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