Risk of torsades de pointes with non-cardiac drugs. Doctors need to be aware that many drugs can cause qt prolongation

Editorial

Y G Yap et al. BMJ. 2000.

. 2000 Apr 29;320(7243):1158-9.

doi: 10.1136/bmj.320.7243.1158.

No abstract available

Comment in

Risk of torsades de pointes with non-cardiac drugs. Prolongation of QT interval is probably a class effect of fluoroquinolones.
Iannini PB, Doddamani S, Byazrova E, Curciumaru I, Kramer H. Iannini PB, et al. BMJ. 2001 Jan 6;322(7277):46-7. BMJ. 2001. PMID: 11141163 Free PMC article. No abstract available.
Risk of torsades de pointes with non-cardiac drugs. Grapefruit juice is source of potentially life threatening adverse drug reactions.
Marinucci P. Marinucci P. BMJ. 2001 Jan 6;322(7277):47. BMJ. 2001. PMID: 11141164 No abstract available.
Registry for torsades de pointes with drug treatment exists.
Kilborn MJ, Woosley RL. Kilborn MJ, et al. BMJ. 2001 Mar 17;322(7287):672-3. BMJ. 2001. PMID: 11250861 Free PMC article. No abstract available.

1. Simons FER, Kesselmann MS, Giddings NG, Pelech AN, Simons KJ. Astemizole-induced torsades de pointes. Lancet. 1988;ii:624. - PubMed
1. Woosley RL, Chen Y, Freiman JP, Gilles RA. Mechanism of the cardiotoxic actions terfenadine. JAMA. 1993;269:1532–1536. - PubMed
1. Lindquist M, Edwards IR. Risks of non-sedating antihistamines. Lancet. 1997;349:1322. - PubMed
1. Gitler B, Berger LS, Buffa SD. Torsades de pointes induced by erythromycin. Chest. 1994;105:368–372. - PubMed
1. White NJ, Looareesuwan S, Warrell DA. Quinine and quinidine: a comparison of EKG effects during the treatment of malaria. J Cardiovasc Pharmacol. 1983;5:173–175. - PubMed