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. 1979 Feb;37(2):222-6.
doi: 10.1128/aem.37.2.222-226.1979.

Conversion of 2,4,6-trinitrophenol to a mutagen by Pseudomonas aeruginosa

J F Wyman, H E Guard, W D Won, J H Quay

Conversion of 2,4,6-trinitrophenol to a mutagen by Pseudomonas aeruginosa

J F Wyman et al. Appl Environ Microbiol. 1979 Feb.

Abstract

A strain of Pseudomonas aeruginosa reduced 2,4,6-trinitrophenol (picric acid) to 2-amino-4,6-dinitrophenol (picramic acid) under anaerobic conditions. Mutagenic assays of picric acid and picramic acid were carried out with histidine-requiring strains of Salmonella typhimurium. Picric acid (10 micrograms per plate) demonstrated mutagenicity (both frame shift and base substitution-gype mutations) only after activation with a rat liver homogenate preparation. Picramic acid (1 microgram per plate) induced both base pair substitution and frame shift-tupe mutations without activation by the rat liver preparation.

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References

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