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. 1975 Feb;114(2 Pt 1):581-4.

Preliminary evidence for cell-mediated immunity in cross-protection among group A arboviruses

R D Peck, A Brown, C J Wust
  • PMID: 1079033

Preliminary evidence for cell-mediated immunity in cross-protection among group A arboviruses

R D Peck et al. J Immunol. 1975 Feb.

Abstract

Unfractionated and T cell-enriched populations from spleens of mice immunized with Sinbdis virus confer cross-protection against Semliki forest virus challenge in recipient mice. Both Group A viruses are serologically related, but not by tests for cross-neutralizing antibody. The protection in mice persisted for three consecutive cell passages in uninfected mice. The results suggest that cell-mediated immunity accounts for cross-protection.

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