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Comment
. 2000 May 1;149(3):529-30.
doi: 10.1083/jcb.149.3.529.

Quo vadis: polarized membrane recycling in motility and phagocytosis

I Mellman  1
Affiliations
Comment

Quo vadis: polarized membrane recycling in motility and phagocytosis

I Mellman. J Cell Biol. .
No abstract available

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Figures

Figure 1
Figure 1
Proposed polarized insertion of recycling plasma membrane components during phagocytosis and cell motility. Plasma membrane internalized during clathrin-mediated endocytosis is first delivered to peripheral early endosomes from which the majority of membrane components recycles rapidly back to the cell surface. A fraction is delivered, however, to a perinuclear population of recycling endosomes enriched in the v-SNARE VAMP3/Cellubrevin (blue). During phagocytosis, membrane from this recycling endosome population must be recruited, in a tetanus toxin–sensitive VAMP3/Cellubrevin-dependent fashion, to the site of particle uptake to allow for pseudopod extension. Conceivably, much the same may occur during the process of cell migration, namely that recycling endosomes fuse at a cell's leading edge providing membrane to allow forward extension of the migrating cell.
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