Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2000 May 1;149(3):529-30.
doi: 10.1083/jcb.149.3.529.

Quo vadis: polarized membrane recycling in motility and phagocytosis

I Mellman  1
Affiliations
Comment

Quo vadis: polarized membrane recycling in motility and phagocytosis

I Mellman. J Cell Biol. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Proposed polarized insertion of recycling plasma membrane components during phagocytosis and cell motility. Plasma membrane internalized during clathrin-mediated endocytosis is first delivered to peripheral early endosomes from which the majority of membrane components recycles rapidly back to the cell surface. A fraction is delivered, however, to a perinuclear population of recycling endosomes enriched in the v-SNARE VAMP3/Cellubrevin (blue). During phagocytosis, membrane from this recycling endosome population must be recruited, in a tetanus toxin–sensitive VAMP3/Cellubrevin-dependent fashion, to the site of particle uptake to allow for pseudopod extension. Conceivably, much the same may occur during the process of cell migration, namely that recycling endosomes fuse at a cell's leading edge providing membrane to allow forward extension of the migrating cell.
See this image and copyright information in PMC

Comment on

References

    1. Aderem A., Underhill D.M. Mechanisms of phagocytosis in macrophages. Annu. Rev. Immunol. 1999;17:593–623. - PubMed
    1. Bajno L., Peng X.-R., Schreiber A.D., Moore H.-P., Trimble W.S., Grinstein S. Focal exocytosis of VAMP3-containing vesicles at sites of phagosome formation. J. Cell Biol. 2000;149:697–705. - PMC - PubMed
    1. Bretscher M.S. Getting membrane flow and the cytoskeleton to cooperate in moving cells. Cell. 1996;87:601–606. - PubMed
    1. Bretscher M.S., Aguado-Velasco C. Membrane traffic during cell locomotion. Curr. Opin. Cell Biol. 1998;10:537–541. - PubMed
    1. Daro E., van der Sluijs P., Galli T., Mellman I. Rab4 and cellubrevin define different early endosome populations on the pathway of transferrin receptor recycling. Proc. Natl. Acad. Sci. USA. 1996;93:9559–9564. - PMC - PubMed