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. 1975 Mar;28(3):479-84.

Antigen-binding T and B lymphocytes in sensitization and unresponsiveness to dinitrochlorobenzene (DNCB) contact sensitivity

L Polak, A Rydén, G E Roelants

Antigen-binding T and B lymphocytes in sensitization and unresponsiveness to dinitrochlorobenzene (DNCB) contact sensitivity

L Polak et al. Immunology. 1975 Mar.

Abstract

The frequency of DNP-binding T and B lymphocytes was studied in various states of sensitization and unresponsiveness to DNCB contact sensitivity. In guinea-pigs, where unresponsiveness to DNCB had been established with DNBSO3 by pretreatment or during the primary response, no increase in antigen-binding cell frequency was found after antigenic stimulation. On the contrary, DNCB-sensitive guinea-pigs, later desensitized with DNBSO3, showed the same frequency of antigen-binding cells as sensitized animals, although they were unable to react to DNCB.

These results confirm and extend the idea of a different mechanism for `tolerance' and `desensitization' to contact sensitivity.

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