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. 2000 Apr;142(4):645-52.
doi: 10.1046/j.1365-2133.2000.03408.x.

Thyroid hormone receptor beta1 is expressed in the human hair follicle

N Billoni  1 , B Buan, B Gautier, O Gaillard, Y F Mahé, B A Bernard
Affiliations

Thyroid hormone receptor beta1 is expressed in the human hair follicle

N Billoni et al. Br J Dermatol. 2000 Apr.

Abstract

To understand better the mechanisms by which thyroid hormone can exert its effects on the hair follicle, we looked for the expression of members of the thyroid hormone receptor (TR) family in human hair follicles. Immunoreactive TRs were detected in both dermal and epithelial compartments of the human pilosebaceous unit. Using reverse transcriptase-polymerase chain reaction, we established that TRbeta1 was the predominant form of TR expressed in the human hair follicle. In addition, we investigated the effects of 3,3', 5-triiodo-L-thyronine (T3) on the survival of human hair follicles in vitro, to understand the role of this thyroid hormone on hair follicle homeostasis. A physiological level of free T3 significantly enhanced human hair survival in vitro.

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Comment in

  • Thyroid hormone and hair growth.
    Messenger AG. Messenger AG. Br J Dermatol. 2000 Apr;142(4):633-4. doi: 10.1046/j.1365-2133.2000.03521.x. Br J Dermatol. 2000. PMID: 10792210 No abstract available.

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